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. 2022 Feb 28;12:3303. doi: 10.1038/s41598-022-07133-3

Table 2.

Open field parameters on day 7, 13 and 20. Data are pooled and presented as main effects of diet and birth weight (n = 18). Data are shown as mean ± SD. All data were analysed using a linear mixed model and p < 0.05 is considered statistically significant. VEG vegetable oil, MILK bovine milk fat, NBW normal birth weight, IUGR intrauterine growth restricted.

Parametera Day 7 Day 13 Day 20 p valueb
VEG MILK NORM IUGR VEG MILK NORM IUGR VEG MILK NORM IUGR pDIET pWEIGHT
Distance m 27.1 ± 11.0 26.5 ± 11.0 29.5 ± 10.8 24.1 ± 10.6 37.0 ± 13.3 35.3 ± 13.1 40.0 ± 15.0 32.3 ± 9.65 36.2 ± 9.67 36.7 ± 17.3 38.9 ± 16.1 34.0 ± 10.9 0.8 0.09
Velocity cm/s 11.3 ± 4.59 11.1 ± 4.60 12.3 ± 4.49 10.1 ± 4.40 15.4 ± 5.56 14.7 ± 5.44 16.7 ± 6.24 13.4 ± 4.02 15.1 ± 4.02 15.3 ± 7.20 16.2 ± 6.73 14.2 ± 4.54 0.8 0.09
Zone 1 s 14.0 ± 18.2 7.41 ± 9.26 9.51 ± 10.5 11.9 ± 18.1 14.4 ± 15.7 10.9 ± 10.5 15.2 ± 14.4 10.1 ± 12.0 9.42 ± 11.0 11.9 ± 8.28 7.16 ± 4.88 14.1 ± 12.0 0.7 0.9
Zone 2 s 41.1 ± 37.2 38.5 ± 24.1 47.6 ± 22.0 31.9 ± 36.8 42.2 ± 21.7 35.8 ± 22.9 44.8 ± 24.4 33.3 ± 18.8 32.2 ± 25.3 25.7 ± 24.6 33.6 ± 26.6 24.3 ± 22.8 0.5 0.06
Zone 3 s 8.93 ± 11.8 10.0 ± 11.4 14.1 ± 13.5 4.84 ± 6.53 13.9 ± 16.0 16.8 ± 15.7 15.7 ± 15.7 15.0 ± 16.2 7.24 ± 8.03 6.48 ± 7.67 5.84 ± 6.78 7.88 ± 8.69 0.3 #
Zone 4 s 6.18 ± 11.6 6.82 ± 9.38 6.82 ± 9.87 6.18 ± 11.2 9.60 ± 12.7 6.95 ± 8.84 6.97 ± 8.14 9.57 ± 13.2 4.97 ± 5.79 9.14 ± 15.1 3.38 ± 4.54 10.7 ± 14.9 0.8 0.5
Center s 72.8 ± 49.8 69.5 ± 39.2 59.7 ± 39.2 82.7 ± 47.0 54.1 ± 26.6 68.8 ± 47.7 60.1 ± 44.1 62.7 ± 33.9 80.5 ± 34.5 88.9 ± 49.3 89.4 ± 47.5 80.1 ± 36.9 0.6 0.7
Periphery s 167 ± 49.8 171 ± 39.2 180 ± 39.1 157 ± 47.0 186 ± 26.6 171 ± 47.6 180 ± 44.0 177 ± 33.9 160 ± 34.5 151 ± 49.3 151 ± 47.5 160 ± 36.9 0.2 0.8
Rearings 0.56 ± 1.46 1.11 ± 2.56 0.94 ± 2.26 0.72 ± 1.93 3.28 ± 3.55 3.00 ± 3.58 3.06 ± 2.75 3.22 ± 4.22 1.11 ± 1.41 0.78 ± 1.93 1.00 ± 1.85 0.89 ± 1.53 0.5 0.9

#A weight × day interaction for time spent in zone 3 of the arena is present (day 7: p < 0.01, day 13: p = 0.8, day 20: p = 0.6).

aSupplementary Fig. S1 defines each zone of the open field arena.

bThe overall p value indicating differences between either dietary or weight groups over time.