Table 2: Sensitivity analysis of association between CHIP and Stroke in WHI adjusted for additional covariates.

In the primary analysis age, sex and PC 1–10 were included as covariates. Sensitivity analysis presented here was performed additionally adjusting for diabetes, smoking history and hypertension, which did not explain the association, and demonstrated a stronger association with additional adjustment. (CHIP, Clonal Hematopoiesis of Indeterminate Potential; HR, Hazard Ratio; SE, Standard Error; VAF, Variant Allele; HTN, Hypertension)

Outcome	CHIP Clone Size	Covariates	HR	beta	SE	P-value
Stroke	VAF ≥2%	age, sex, PC1–10	1.17	0.16	0.09	0.09
Stroke	VAF ≥2%	age, sex, PC1–10, Diabetes, smoking, HTN	1.23	0.20	0.09	0.03
Stroke	VAF ≥ 10%	age, sex, PC1–10	1.12	0.11	0.10	0.25
Stroke	VAF ≥ 10%	age, sex, PC1–10, Diabetes, smoking, HTN	1.15	0.14	0.10	0.15
Ischemic Stroke	VAF ≥2%	age, sex, PC1–10	1.15	0.14	0.11	0.18
Ischemic Stroke	VAF ≥2%	age, sex, PC1–10, Diabetes, smoking, HTN	1.21	0.19	0.11	0.08
Ischemic Stroke	VAF ≥ 10%	age, sex, PC1–10	1.10	0.09	0.11	0.40
Ischemic Stroke	VAF ≥ 10%	age, sex, PC1–10, Diabetes, smoking, HTN	1.13	0.12	0.11	0.26
Hemorrhagic Stroke	VAF ≥2%	age, sex, PC1–10	1.37	0.31	0.13	0.02
Hemorrhagic Stroke	VAF ≥2%	age, sex, PC1–10, Diabetes, smoking, HTN	1.41	0.35	0.13	0.01
Hemorrhagic Stroke	VAF ≥ 10%	age, sex, PC1–10	1.30	0.26	0.14	0.07
Hemorrhagic Stroke	VAF ≥ 10%	age, sex, PC1–10, Diabetes, smoking, HTN	1.32	0.28	0.14	0.05