Table 3: Association of CHIP with subtypes of stroke within the WHI.

The Trial of Org 10172 in Acute Stroke Treatment (TOAST) defined subtypes of ischemic and hemorrhagic stroke, which are used in standard practice. Here, additional analysis was done within the WHI cohort to investigate the relationship between CHIP and stroke subtypes. CHIP was not associated with increased risk of LAS or CES. CHIP was, however, significantly associated with an increased hazard ratio for SVS Ischemic Stroke (P=0.001) and SAH Hemorrhagic Stroke (P=0.004), as well as a relationship with ICH Hemorrhagic Stroke approaching significance (P=0.06). (CHIP, Clonal Hematopoiesis of Indeterminate Potential; WHI, Women’s Health Initiative; TOAST, Trial of Org 10172 in Acute Stroke Treatment; LAS, Large Artery Stroke; CES, Cardioembolic Stroke; SVS, Small Vessel Stroke; SAH, Subarachnoid Hemorrhage; ICH, intracerebral hemorrhage; SE, standard error).

Outcome	Total (n)	Event (n)	Hazard Ratio	Beta	SE	P value
All Stroke	9711	4588	1.23	0.21	0.07	0.006
Ischemic Stroke	8875	3752	1.19	0.17	0.08	0.033
Hemorrhagic Stroke	5935	812	1.44	0.37	0.13	0.004
LAS Ischemic Stroke	5396	273	1.12	0.11	0.23	0.618
CES Ischemic Stroke	6282	1159	1.05	0.05	0.12	0.684
SVS Ischemic Stroke	5827	704	1.55	0.44	0.13	0.001
SAH Hemorrhagic Stroke	5302	179	1.98	0.68	0.24	0.004
ICH Hemorrhagic Stroke	5737	614	1.31	0.27	0.15	0.063