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. 2022 Feb 15;9:833171. doi: 10.3389/fcvm.2022.833171

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Copyright © 2022 Demissei, Lv, Wilcox, Sheline, Smith, Sturgeon, McDermott-Roe, Musunuru, Lefebvre, Domchek, Shah and Ky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Age-adjusted marginal mean (95% Confidence Interval) estimates of echocardiography and cardiopulmonary exercise testing measures according to exposure group. The figure presents the age-adjusted marginal mean (95% confidence interval) estimates based on analysis of covariance for measures of systolic function, diastolic function and cardiopulmonary exercise testing according to exposure group including (a) BRCA1/2 mutation carriers exposed to doxorubicin, (b) BRCA1/2 mutation carriers not exposed to doxorubicin, and (c) BRCA1/2 mutation non-carriers exposed to doxorubicin. For longitudinal and circumferential strain, absolute values are presented, where by a higher value represents greater function.