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. 2022 Feb 28;12:3278. doi: 10.1038/s41598-022-07153-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Impact on anti-PD-1 antibody response across syngeneic models (A) Growth curves of MC38, Hepa-1–6, CT26 and EMT-6 subcutaneous tumors following depletion of specific immune lineages with anti-PD-1 treatment (10 mg/kg) and (B) TGI summarized in a bar plot (% relative to non-treated control). (C) Heat map showing dynamic TIL changes in all 4 subcutaneous tumors following depletion of specific immune lineages (% TIL relative to anti-PD-1 control) represented as either positive or negative values (red or blue shading respectively) with the intensity of color positively-correlating with the absolute value of % change (plotted using R v3.5.2). Text highlighted in red shows significant (p value < 0.05) % changes.