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. 2022 Feb 28;12:3278. doi: 10.1038/s41598-022-07153-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of targeted immune cell depletion in DTR transgenic mice; (A) Heat map of TIL pharmacodynamic assessed by FACS (% TIL relative to untreated control) in DTR mice bearing MC38 tumors following specific immune cell depletion, represented as either positive or negative values (red or blue shading respectively) with the intensity of color positively correlating with the absolute value of % change (plotted using R v3.5.2). Text highlighted in red shows significant (p value < 0.05) % changes. (B) Growth curve of Hepa-1–6 subcutaneous tumors following treatment of Foxp3-DTR mice with DT with and without anti-PD-1 treatment (10 mg/kg) with (C) TGI summarized in a bar plot (% relative to non-treated control).