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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Brain Behav Immun. 2021 Dec 23;101:1–22. doi: 10.1016/j.bbi.2021.12.017

Figure 11. Chronic SCI alters different neuroinflammatory pathways in the injury site of male and female mice.

Figure 11.

(A) Graph illustrating the neuroinflammatory genes altered by spinal cord injury in different sexes. Injury genes in male mice indicated higher alteration in Carbohydrate Metabolism and Lipid Metabolism. Female mice indicated higher levels of alteration in Angiogenesis, Apoptosis, Autophagy, Cellular Stress, Cytokine Signaling and Wnt Signaling pathways. (B) Heatmap of genes that are altered in DE between SCI/Female and SCI/Male, 10 of the genes that were different at baseline in Sham mice and 11 genes that were only DE under injury conditions. Color coding was based on z-score scaling. (C) Heatmap of genes that are uniquely altered in DE by sex late after SCI, genes only altered in Set 4. Color coding based on z-scores of normalized transcription counts.