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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Brain Behav Immun. 2021 Dec 23;101:1–22. doi: 10.1016/j.bbi.2021.12.017

Figure 13. Chronic SCI alters different neuroinflammatory pathways in the cerebral cortex of male and female mice.

Figure 13.

(A) Graph illustrating the neuroinflammatory genes altered by spinal cord injury in different sexes. Injury genes in male mice indicated higher alteration in Carbohydrate Metabolism and Lipid Metabolism. Female mice indicated higher levels of alteration in Angiogenesis, Apoptosis, Autophagy, Cellular Stress, Cytokine Signaling and Wnt Signaling pathways. (B) Heatmap of genes that are altered in differential expression between SCI/Female and SCI/Male, 10 of the genes overlap with those of. Color coding was based on z-score scaling. (C) Pathway analysis of genes unique to sex dimorphism after injury.