Table 4.
Studies reporting health-related quality of life outcomes enrolling only elderly patients with HNSCC.
| Author | Year | n | Location | Ages included | Participants | Instrument | Study design | Findings |
|---|---|---|---|---|---|---|---|---|
| Dimovska et al. (28) | 2016 | 34 | United Kingdom | ≥80 years | Sx with microsurgical reconstruction | UW-QoL (v4) | Cross-sectional | Overall score represented mean of the physical and socioemotional domains, 78.7; physical function mean score, 76.52; socioemotional mean score, 80.9 |
| Fang et al. (29) | 2014 | 59 | China | ≥70 years | Comparison of surgical patients with and without free flap reconstruction | UW-QoL (v4.0) | Cross-sectional (≥12m post Rx) | Mean composite QoL similar (77.5 vs 72.1, p=0.231); SS differences favoring free flap group in chewing (69.0 vs 57.0) |
| Ferri et al. (10) | 2019 | 39 | Italy | >75 years | Sx with microsurgical reconstruction | SF-36 | Cross-sectional | Average score of all scales was 68.3; MCS, 44.6; PCS, 46.5 Highest scale: Physical, 76.92; Lowest scale: energy/fatigue, 60.25 Compared to general population: PCS was higher in this group (46.53 vs 37.85) |
| Ruhle et al. (30) | 2021 | 50 | Germany | ≥65 years | Definitive and adjuvant RT/CRT | QLQ-C30 QLQ-H&N35 |
Cross-sectional (≥12m post Rx) | Median global QoL (66.7) comparable to German age- and gender matched cohort (65.3); Global QoL similar between definitive and adjuvant CRT (median 75 vs 66.7, p=0.219); HPV+ had superior global QoL to HPV- |
HPV, human papillomavirus, MCS, Medical Component Summary; PCS, Physical Component Summary; QoL, quality of life; QLQ-C30, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30; QLQ-H&N35, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Head and Neck module; Rx, treatment; SF-36, Short Fom-36 Health Survey; Sx, surgery; UW-QoL, University of Washington Quality of Life instrument.