Table 3.
Laboratory values of patients meeting modified criteria for multisystem inflammatory syndrome in adults with discharge during March–December 2020 in the Premier Healthcare Database Special COVID-19 Release
| All patients N = 53 |
Patients <50 years-old N = 12 |
Patients ⩾50 years-old N = 41 |
P-value | |
|---|---|---|---|---|
| Blood cell countsa – n (%) | ||||
| Leucocytosis | 26 (53.1) N = 49 |
10 (83.3) N = 12 |
16 (43.2) N = 37 |
0.02 |
| Neutrophilia | 28 (58.3) N = 48 |
9 (90.0) N = 10 |
19 (50.0) N = 38 |
0.03 |
| Lymphopenia | 36 (76.6) N = 47 |
6 (75.0) N = 8 |
30 (76.9) N = 39 |
1.00 |
| Anemia | 40 (75.5) N = 53 |
9 (75.0) N = 12 |
31 (75.6) N = 41 |
1.00 |
| Thrombocytopenia | 26 (49.1) N = 53 |
7 (58.3) N = 12 |
19 (46.3) N = 41 |
0.53 |
| Markers of inflammation – median (IQR) | ||||
| C-reactive protein (mg/dl) | 14.1 (9.8–24.0) N = 50 |
22.3 (15.6–36.8) N = 12 |
11.3 (8.4–21.3) N = 38 |
0.03 |
| Erythrocyte sedimentation rate (mm/h) | 48 (27–67) N = 17 |
79 (44–98) N = 4 |
47 (27–63) N = 13 |
0.23 |
| Ferritin (ng/ml) | 751 (270–2560) N = 46 |
1052 (270–2647) N = 11 |
704 (255–2293) N = 35 |
0.53 |
| Interleukin-6 (pg/ml) | 37.0 (7.7–60.0) N = 9 |
1056 (540–1572) N = 2 |
33.0 (5.0–56.0) N = 7 |
0.09 |
| Procalcitonin (ng/ml) | 0.64 (0.18–4.22) N = 49 |
2.77 (0.75–10.69) N = 12 |
0.40 (0.15–2.18) N = 37 |
0.10 |
| Markers of organ dysfunctionc – n (%) | ||||
| Elevated cardiac troponinb | 31 (68.9) N = 45 |
6 (66.7) N = 9 |
25 (69.4) N = 36 |
1.00 |
| Elevated BNP or NT-proBNP | 26 (78.8) N = 33 |
6 (85.7) N = 7 |
20 (76.9) N = 26 |
1.00 |
| Elevated creatinine | 28 (52.8) N = 53 |
5 (41.7) N = 12 |
23 (56.1) N = 41 |
0.51 |
| Elevated alanine aminotransferase | 21 (41.2) N = 51 |
7 (58.3) N = 12 |
14 (35.9) N = 39 |
0.20 |
IQR, interquartile range; BNP, B-type natriuretic peptide; NT-proBNP, N-terminal proB-type natriuretic peptide.
Thresholds for blood cell counts: Leucocytosis = absolute lymphocyte count >11.0 K/μl, Neutrophilia = absolute neutrophil count >8.0 K/μl, Lymphopenia = absolute lymphocyte count <1.0 K/μl, Anaemia = haemoglobin <14.0 mg/dl (men), <12.0 mg/dl (women), Thrombocytopenia = platelets <150 K/μl.
Includes both troponin-I and troponin-T. Troponin values were classified as elevated or normal based on the reference range used by the testing hospital laboratory.
Thresholds for markers of organ dysfunction: Elevated B-type natriuretic peptide = >100 pg/ml, Elevated N-terminal proB-type natriuretic peptide = >450 pg/ml, Elevated creatinine = >1.3 mg/dl, Elevated alanine aminotransferase = >55 IU/l.