Table 2.

EBMT recommendations for haploidentical donor selection, by order.

T-cell-depleted haploidentical transplants	T-cell-replete haploidentical transplants
No DSAs (MFI  <  1,000)	No DSAs (MFI < 1,000)
NK cell alloreactive donor	Younger donor over older donor
Younger donor over older donor	Male donor for a male recipient
Male donor for a male recipient	Sibling or offspring donor over parent donor
First-degree relative over second-degree HLA half-matched donor	Between parent donors, the father is preferred over the mother
Between parent donors, the mother is preferred over the father	ABO matched is preferred to minor ABO mismatch to major ABO mismatched donora
ABO matched donor	Donor with KIR ligand match for a recipient of HHCTa
CMV seropositive donor for CMV seropositive recipients First-degree relative over second-degree HLA half-matched donor Donor with NIMA mismatch over NIPA mismatch for a recipient of HHCTa	Donor with NIMA mismatch over NIPA mismatch for a recipient of HHCTa

From “The European Society for Blood and Marrow Transplantation (EBMT) consensus recommendations for donor selection in haploidentical hematopoietic cell transplantation” Ciurea et al. (60).

^aConclusive data available with the Beijing protocol only.