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. 2022 Feb 15;13:851028. doi: 10.3389/fimmu.2022.851028

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Copyright © 2022 James, Matheny, Overby, Sim, Eappen, Li, Li, Richie, Chakravarty, Gunasekera, Murshedkar, Billingsley and Hoffman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sagittal sectional schematic diagram of an IMTC. The inner container (IC) is housed inside the outer container (OC), which is a custom machined 1 L polycarbonate container with screw top and screw base. All nine locations used for placement of alanine transfer dosimeters for mapping are indicated. The minimum dose of irradiation was recorded at position F up to the time when a new IC was incorporated when the minimum dose location changed to D. The maximum dose location is position H. The reference dosimeter used in PfSPZ Vaccine manufacturing runs is located at position B. The relationship between the dose received at B to the dose received at D (or previously, F) and between the dose at B and the dose at H are used to generate the formulae for estimating the doses at positions D/F and H during vaccine production.