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Regulation of viral cloaking by cyclophilin A. (Left panel) CypA modulates the ability of HCV and EAV to form membranous replication organelles, likely through direct or indirect interactions with HCV NS5A or EAV Nsp5, respectively. (Right panel) CypA enhances the stability of the HIV-1 capsid, thus prevent premature cytoplasmic uncoating. MxB inhibits HCV and HIV-1 replication in a CypA-dependent manner, likely disrupting viral cloaking.
