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. 2022 Feb 15;13:828983. doi: 10.3389/fphar.2022.828983

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Copyright © 2022 Xu, Zhuo, Liu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptomic and proteomic profiling of A431 cells treated with itraconazole. (A) Volcano plot of RNA-seq data. The horizontal line represents a p-value of .01, whereas the vertical lines correspond to 1.5-fold increase and decrease. (B) Volcano plot of iTRAQ data. The horizontal line represents a p-value of .05, whereas the vertical lines correspond to 1.5-fold increase and decrease. (C) GO enrichment analysis of BP, CC and MF. (D) The intersection of transcriptomic and proteomic profiling datasets showed overlap of 34 upregulated proteins in A431 cells.