Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 15;13:828983. doi: 10.3389/fphar.2022.828983

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Xu, Zhuo, Liu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Itraconazole induces ferroptosis through upregulating ACSL4 expression. (A) The relative mRNA expression level of ACSL4 was presented by qRT-PCR. (B) The protein expression level of ACSL4 was presented by western blot. Relative level of MDA (C) and iron (D) in A431 cells treated with itraconazole were investigated by specific kits. (E) The relative mRNA expression level of ACSL4 and HMGCS1 in A431 sh-Con and A431 sh-HMGCS1#2 was presented by qRT-PCR. (F) The protein expression level of ACSL4 and HMGCS1 in A431 sh-Con and A431 sh-HMGCS1#2was presented by western blot. Relative level of MDA (G) and iron (H) in A431 sh-Con and A431 sh-HMGCS1#2 treated with itraconazole were showed. [mean ± SD (error bars), n = 3; *p ≤ .05; **p ≤ .01; ***p ≤ .001, compared with control group].