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. 2022 Feb 15;13:828983. doi: 10.3389/fphar.2022.828983

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Copyright © 2022 Xu, Zhuo, Liu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Itraconazole significantly inhibits cSCC cells in a xenograft model. (A) Nude mice with A431 subcutaneous tumor xenografts were treated with Normal saline (n = 7), 40 mg/kg (n = 7) or 80 mg/kg (n = 7) itraconazole twice daily by oral gavage for nearly 3 weeks. During drug treatment, tumor volumes were monitored every 2 days. Mice were euthanized at Day-24 after transplantation, tumors were photographed (B,C) weighted individually. Representative immunohistochemical analysis of Ki67(D, ×400), cleaved caspase-3 (D, ×400), HMGCS1 (D, ×400), ACSL4 (D, ×400) protein levels of tumor xenografts and H&E staining analysis of liver (D, ×100) in each group (Scale bar of tumor slides: 100 μm; Scale bar of liver slides: 500 μm). *p < .05; **p < .01; ***p < .001; Itra, itraconazole.