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Pathogenesis of obese-DM-HFpEF. RAAS: Renin-Angiotensin-Aldosterone system, CRP: C-Reactive Protein, IL -6: lnterleukin-6, VCAM-1: Vascular cell adhesion molecule 1, MCP-1: monocycte chemoattractant protein-1,TNF-α: Tumor Necrosis Factor alpha, NLRP-3: Nod-Like receptor protein 3, ROS: Reactive oxygen species, NO: Nitric Oxide, PKG: Protein Kinase G.
