FIGURE 4.
Increase in 2-arachidonoyl glycerol (2-AG) levels but not in anandamide (AEA) levels in the ovaries of SCID-SHO female mice with OVCAR-5 ectopic xenograft tumors receiving chronic systemic administration of JWH-133. JWH-133 (1 mg/kg i.p.) chronic administration for 30 days starting on day 30 of tumor growth produced an increase in 2-AG (A) levels in the ovaries of OVCAR-5 ectopic xenograft female mice relative to the vehicle treated group. No changes in AEA (B) levels were observed following chronic administration of JWH-133 relative to vehicle-treated group in the ovaries of OVCAR-5 ectopic xenograft female mice. Symbols represent the means ± SEM. (ovaries of OVCAR-5 tumor in SCID-SHO female mice receiving vehicle, n = 4-6 SCID-SHO females; ovaries of OVCAR-5 tumor in SCID-SHO female mice receiving JWH-133, n = 6 SCID-SHO females). *p < 0.0386 unpaired t-test (t11 = 1.950, one-tailed).