Table 2.
Significant different subclasses of lipids of T0(n = 26) verse control (n = 10).
| LipidIon | Class | Calmz | IonFormula | RT-(min) | Fold Change | P-value | VIP |
|---|---|---|---|---|---|---|---|
| SM(d32:1)+HCOO | SM | 719.53 | C38 H76 O8 N2 P1 | 8.743304 | 105.5802817 | 0.03955 | 1.27158 |
| OAHFA(18:1/34:1)-H | OAHFA | 785.74 | C52 H97 O4 | 20.93825 | 52.16343297 | 0.03692 | 2.29603 |
| Co(Q10)+NH4 | Co | 880.72 | C59 H94 O4 N1 | 17.96348 | 49.2154925 | 0.03669 | 1.0111 |
| OAHFA(18:1/32:2)-H | OAHFA | 755.69 | C50 H91 O4 | 18.67636 | 36.6853155 | 0.0444 | 2.04926 |
| OAHFA(18:1/32:1)-H | OAHFA | 757.71 | C50 H93 O4 | 19.74312 | 29.63556255 | 0.04736 | 3.88388 |
| SM(d40:2)+H | SM | 785.65 | C45 H90 O6 N2 P1 | 12.00555 | 21.94609662 | 0.03554 | 1.3621 |
| TG(26:0/16:0/18:1)+Na | TG | 995.9 | C63 H120 O6 Na1 | 24.44222 | 21.32021673 | 0.02028 | 1.07358 |
| Cer(d18:1/16:0+O)+H | Cer | 554.51 | C34 H68 O4 N1 | 10.187 | 14.87557017 | 0.01568 | 2.56661 |
| PC(35:2)+H | PC | 772.59 | C43 H83 O8 N1 P1 | 10.84815 | 13.45758007 | 0.01122 | 1.40963 |
| PC(34:2)+H | PC | 758.57 | C42 H81 O8 N1 P1 | 10.35652 | 9.044793221 | 0.02042 | 1.48086 |
| LPC(18:1)+H | LPC | 522.36 | C26 H53 O7 N1 P1 | 2.829591 | 8.862523744 | 0.03903 | 1.58635 |
| LPE(18:1)-H | LPE | 478.29 | C23 H45 O7 N1 P1 | 2.971951 | 8.196791624 | 0.0116 | 1.41347 |
| Cer(d16:1/18:0)+HCOO | Cer | 582.51 | C35 H68 O5 N1 | 11.30124 | 8.162108672 | 0.00901 | 2.41341 |
| SM(d42:1)+H | SM | 815.7 | C47 H96 O6 N2 P1 | 14.09983 | 7.808909475 | 0.00453 | 1.11772 |
| TG(16:0/18:2/18:3)+Na | TG | 875.71 | C55 H96 O6 Na1 | 18.71938 | 7.301180438 | 0.0205 | 1.9029 |
| LPC(18:1)+HCOO | LPC | 566.35 | C27 H53 O9 N1 P1 | 2.824801 | 7.164012181 | 0.00877 | 2.12477 |
| SM(d38:1)+H | SM | 759.64 | C43 H88 O6 N2 P1 | 12.02927 | 7.023899481 | 0.0079 | 1.35097 |
| SM(d18:1/16:0)+HCOO | SM | 747.57 | C40 H80 O8 N2 P1 | 9.977419 | 7.005964358 | 0.02223 | 2.06393 |
| TG(16:1/18:1/18:2)+NH4 | TG | 872.77 | C55 H102 O6 N1 | 19.68893 | 6.980513631 | 0.03026 | 1.53642 |
| PS(39:1)-H | PS | 830.59 | C45 H85 O10 N1 P1 | 11.36284 | 6.821055558 | 0.03541 | 3.19895 |
| PS(37:1)-H | PS | 802.56 | C43 H81 O10 N1 P1 | 10.3793 | 6.474225864 | 0.02929 | 1.56783 |
| TG(16:0/18:2/20:5)+H | TG | 877.73 | C57 H97 O6 | 19.659 | 5.818026726 | 0.00493 | 2.28256 |
| TG(18:1/18:2/20:5)+H | TG | 903.74 | C59 H99 O6 | 19.71597 | 5.444758925 | 0.00554 | 1.3387 |
| SM(d40:1)+H | SM | 787.67 | C45 H92 O6 N2 P1 | 13.02854 | 4.693025458 | 0.01777 | 1.03408 |
| LPC(16:0)+HCOO | LPC | 540.33 | C25 H51 O9 N1 P1 | 2.693533 | 4.427438179 | 0.0351 | 3.57942 |
| So(d18:1)+H | So | 300.29 | C18 H38 O2 N1 | 2.422211 | 4.382913682 | 0.00565 | 2.80761 |
| So(d17:1)+H | So | 286.27 | C17 H36 O2 N1 | 2.460979 | 3.940410295 | 3.91E-10 | 2.02106 |
| LPC(18:0)+HCOO | LPC | 568.36 | C27 H55 O9 N1 P1 | 3.790138 | 3.64099302 | 0.03905 | 1.49809 |
| LSM(d20:0)+H | LSM | 495.39 | C25 H56 O5 N2 P1 | 2.831587 | 3.444914731 | 1.08E-05 | 2.89417 |
| Cer(d17:0/2:0)+H | Cer | 330.3 | C19 H40 O3 N1 | 1.913699 | 3.248423375 | 2.35E-06 | 1.85695 |
| LPC(18:2)+H | LPC | 520.34 | C26 H51 O7 N1 P1 | 2.251227 | 2.988598263 | 0.00086 | 1.55151 |
| Cer(d33:0)+H | Cer | 526.52 | C33 H68 O3 N1 | 9.731674 | 2.798888595 | 3.79E-05 | 1.15626 |
| Cer(d35:0)+H | Cer | 554.55 | C35 H72 O3 N1 | 11.36469 | 2.720535667 | 8.07E-06 | 1.35036 |
| TG(16:1/18:1/22:5)+H | TG | 905.76 | C59 H101 O6 | 15.60611 | 2.331510136 | 0.02129 | 1.30254 |
| So(d16:1)+H | So | 272.26 | C16 H34 O2 N1 | 2.666427 | 1.985533979 | 0.01196 | 1.60794 |
| CerG1(d17:1/16:0+O)+H | CerG1 | 702.55 | C39 H76 O9 N1 | 9.514269 | 1.909466251 | 0.00627 | 1.18483 |
| WE(6:0/16:3)+NH4 | WE | 352.32 | H42 C22 O2 N1 | 3.006577 | 1.575320698 | 0.03507 | 1.08855 |
| DGMG(16:0)+HCOO | DGMG | 699.38 | C32 H59 O16 | 2.678107 | 0.468996555 | 0.00695 | 1.61873 |
| DGMG(18:2)+HCOO | DGMG | 723.38 | C34 H59 O16 | 2.225866 | 0.416667634 | 0.02013 | 2.13519 |
| MGMG(18:2)+HCOO | MGMG | 561.33 | C28 H49 O11 | 2.625824 | 0.274625199 | 0.0003 | 1.38641 |
| Cer(d18:1/18:0)+HCOO | Cer | 610.54 | C37 H72 O5 N1 | 12.32153 | 0.144934423 | 0.0018 | 1.9301 |
Comparison of 41 lipid subgroups between MGD group and control group. MGD, meibomian gland dysfunction; T0, before treatment.