Table 1.
Baseline patient characteristics at the first prescription of semaglutide
| Variable | Overall (mean ± SD or %) | Naïve (mean ± SD or %) | Switchers (mean ± SD or %) | p value* |
|---|---|---|---|---|
| N | 216 | 135 | 81 | |
| Age (years) | 64.1 ± 10.4 | 64.1 ± 11.1 | 64.1 ± 9.2 | 0.67 |
| Males (%) | 65.7 | 65.2 | 66.7 | 0.82 |
| Diabetes duration(years) | 12.5 ± 8.3 | 11.4 ± 8.6 | 14.4 ± 7.5 | 0.004 |
| Family history of diabetes(%) | 59.8 | 62.5 | 55.8 | 0.44 |
| Previous cardiovascular disease | 31.0 | 35.6 | 23.5 | 0.06 |
| Stroke | 2.8 | 3.0 | 2.5 | 0.38 |
| Myocardial infarction | 23.6 | 26.7 | 18.5 | |
| Stroke + IMA | 1.9 | 2.2 | 1.2 | |
| Ischemic heart disease | 2.3 | 3.7 | 0.0 | |
| Dilated cardiomyopathy | 0.5 | 0.0 | 1.2 | |
| Years passed from the diagnosis of the first major cardiovascular event(years) | 5.1 ± 4.7 | 4.6 ± 4.0 | 6.5 ± 6.0 | 0.24 |
| Retinopathy (%) | 14.4 | 12.6 | 17.3 | 0.34 |
| History of leg ulcer (%) | 4.6 | 3.0 | 7.4 | 0.18 |
| Smokers (%) | ||||
| Yes | 15.8 | 14.7 | 17.9 | 0.66 |
| No | 47.5 | 46.1 | 50.0 | |
| Ex | 36.7 | 39.2 | 32.1 | |
| HbA1c (%) | 8.4 ± 1.4 | 8.4 ± 1.6 | 8.3 ± 1.3 | 0.79 |
| Obesity indices | ||||
| Waist circumference (cm) | 113.0 ± 14.1 | 114.0 ± 12.9 | 111.2 ± 16.1 | 0.25 |
| Weight (kg) | 94.6 ± 18.7 | 95.0 ± 17.5 | 94.0 ± 20.5 | 0.53 |
| BMI (kg/m2) | 33.5 ± 5.9 | 33.7 ± 5.7 | 33.0 ± 6.3 | 0.21 |
| Blood pressure | ||||
| Systolic (mmHg) | 138.6 ± 16.2 | 137.3 ± 16.4 | 140.6 ± 15.9 | 0.17 |
| Diastolic (mmHg) | 79.9 ± 9.7 | 80.0 ± 9.6 | 79.8 ± 10.0 | 0.83 |
| Lipid profile | ||||
| Total cholesterol (mg/dl) | 170.7 ± 41.9 | 171.3 ± 47.0 | 169.9 ± 33.0 | 0.88 |
| Triglycerides(mg/dl) | 172.4 ± 102.8 | 166.7 ± 96.6 | 181.4 ± 112.0 | 0.23 |
| HDL cholesterol(mg/dl) | 45.0 ± 10.5 | 45.3 ± 11.4 | 44.4 ± 8.9 | 0.87 |
| LDL cholesterol (mg/dl) | 90.0 ± 33.8 | 91.1 ± 37.2 | 88.3 ± 27.9 | 0.96 |
| Renal function | ||||
| Creatinine (mg/dl) | 1.0 ± 0.6 | 0.9 ± 0.3 | 1.1 ± 0.9 | 0.65 |
| eGFR (ml/min*1.73m2) | 79.8 ± 22.0 | 80.3 ± 21.7 | 79.0 ± 22.7 | 0.97 |
| eGFR < 60 ml/min*1.73m2(%) | 18.9 | 18.1 | 20.3 | 0.71 |
| Albuminuria (mg/dl) | 8.2 ± 14.5 | 6.7 ± 11.3 | 10.0 ± 17.6 | 0.20 |
| Hepatic function | ||||
| ALT (iu/l) | 30.3 ± 24.0 | 29.0 ± 21.3 | 32.2 ± 27.5 | 0.87 |
| AST (iu/l) | 28.2 ± 21.7 | 25.6 ± 16.2 | 31.9 ± 27.6 | 0.45 |
| GGT (iu/l) | 45.5 ± 59.3 | 43.1 ± 64.6 | 49.4 ± 49.7 | 0.052 |
| Antihypertensive drugs (%) | 59.7 | 57.8 | 63.0 | 0.45 |
| ARB | 16.2 | 14.8 | 18.5 | 0.47 |
| Diuretic | 21.8 | 23.7 | 18.5 | 0.37 |
| Calcium-antagonists | 27.8 | 25.9 | 30.9 | 0.43 |
| ACE-inhibitor | 29.2 | 25.9 | 34.6 | 0.18 |
| Beta blocker (%) | 28.2 | 30.4 | 24.7 | 0.37 |
| Lipid-lowering agents (%) | 38.4 | 40.7 | 34.6 | 0.37 |
| Statin | 37.0 | 39.3 | 33.3 | 0.38 |
| Ezetemibe | 6.5 | 6.7 | 6.2 | 0.89 |
| Anticoagulants (%) | 4.2 | 2.2 | 7.4 | 0.06 |
| Antiplatelets (%) | 27.8 | 33.3 | 18.5 | 0.02 |
*Unpaired t-test or Mann-Whitney U-test for continuous variables and chi-square test or Fisher exact test for categorical variables, as appropriate
Statistically significant p values (p < 0.05) are in bold