Table 2.
Effectiveness of semaglutide: results of longitudinal models by treatment group
| Change in: | Visit | Naive | Switchers | ||||
|---|---|---|---|---|---|---|---|
| Estimated mean and 95% CI | Estimated mean difference from T0 and 95% CI | Within group p value* |
Estimatedmean and 95% CI | Estimated mean difference from T0 and 95% CI | Within group pvalue* |
||
| HbA1c (%) | T0 |
8.4 (8.19;8.62) |
8.24 (7.95;8.53) |
||||
| T6 |
7.09 (6.85;7.34) |
− 1.31 (− 1.56;− 1.06) |
< 0.0001 |
7.46 (7.14;7.78) |
− 0.78 (− 1.11;− 0.45) |
< 0.0001 | |
| T12 |
7.15 (6.81;7.49) |
− 1.26 (− 1.6;− 0.91) |
< 0.0001 |
7.42 (6.94;7.9) |
− 0.82 (− 1.3;− 0.34) |
0.0001 | |
| Weight (kg) | T0 |
95.25 (92.11;98.39) |
94.44 (90.37;98.52) |
||||
| T6 |
91.34 (88.17;94.5) |
− 3.92 (− 4.79;-3.05) |
< 0.0001 |
91.8 (87.68;95.92) |
− 2.64 (− 3.81;− 1.48) |
< 0.0001 | |
| T12 |
90.03 (86.72;93.34) |
− 5.22 (− 6.51;− 3.93) |
< 0.0001 |
91.32 (87.02;95.62) |
− 3.13 (− 4.8;-1.45) |
0.0003 | |
| BMI (kg/m2) | T0 |
33.77 (32.78;34.77) |
33.11 (31.82;34.4) |
||||
| T6 |
32.34 (31.33;33.34) |
− 1.43 (− 1.74;− 1.13) |
< 0.0001 |
32.11 (30.81;33.42) |
− 1.00 (− 1.4;− 0.59) |
< 0.0001 | |
| T12 |
31.96 (30.9;33.03) |
− 1.81 (− 2.26;− 1.35) |
< 0.0001 |
32.26 (30.88;33.63) |
− 0.85 (− 1.44;− 0.26) |
0.005 | |
| Waist circumference (cm) | T0 |
113.29 (110.62;115.96) |
111.56 (107.75;115.38) |
||||
| T6 |
108.26 (105.56;110.96) |
− 5.03 (− 6.37;− 3.7) |
< 0.0001 |
108.53 (104.64;112.42) |
− 3.03 (− 4.82;− 1.25) |
0.001 | |
| T12 |
107.93 (104.95;110.91) |
− 5.36 (− 7.16;− 3.56) |
< 0.0001 |
109.47 (105.01;113.93) |
− 2.09 (− 4.96;0.77) |
0.15 | |
| Systolic blood pressure (mmHg) | T0 |
137.43 (133.82;141.03) |
140.58 (136.07;145.09) |
||||
| T6 |
138.28 (130.95;145.61) |
0.85 (− 7;8.7) |
0.83 |
136.46 (128.00;144.92) |
− 4.12 (− 13.26;5.02) |
0.37 | |
| T12 |
131.77 (123.34;140.19) |
− 5.66 (− 14.51;3.18) |
0.20 |
132.89 (120.62;145.15) |
− 7.69 (− 20.36;4.98) |
0.23 | |
| Diastolic blood pressure (mmHg) | T0 |
80.07 (78.02;82.13) |
79.72 (77.15;82.3) |
||||
| T6 |
80.51 (76.6;84.42) |
0.43 (− 3.57;4.44) |
0.83 |
77.12 (72.45;81.78) |
− 2.61 (− 7.38;2.17) |
0.28 | |
| T12 |
74.94 (70.51;79.38) |
− 5.13 (− 9.61;− 0.65) |
0.03 |
78.03 (71.69;84.37) |
− 1.69 (− 8.03;4.65) |
0.59 | |
| Total cholesterol (mg/dl) | T0 |
171.18 (163.13;179.23) |
171.5 (161.41;181.59) |
||||
| T6 |
162.32 (152.79;171.86) |
− 8.86 (− 17.09;− 0.63) |
0.04 |
166.8 (155.07;178.52) |
− 4.7 (− 14.37;4.97) |
0.34 | |
| T12 |
157.33 (145.67;168.99) |
− 13.85 (− 24.39;− 3.32) |
0.01 |
162.31 (146.09;178.53) |
− 9.19 (− 23.98;5.61) |
0.22 | |
| Triglycerides (mg/dl) | T0 |
168.43 (150.84;186.03) |
186.64 (164.54;208.75) |
||||
| T6 |
163.83 (141.7;185.97) |
− 4.6 (− 26.32;17.12) |
0.68 |
153.78 (126.93;180.63) |
− 32.86 (− 58.93;− 6.8) |
0.01 | |
| T12 |
155.76 (127.65;183.88) |
− 12.67 (− 40.33;14.99) |
0.37 |
177.81 (138.12;217.5) |
− 8.83 (− 47.74;30.07) |
0.65 | |
| HDL cholesterol (mg/dl) | T0 |
45.14 (43.22;47.06) |
44.28 (41.85;46.71) |
||||
| T6 |
44.38 (42.1;46.66) |
− 0.77 (− 2.68;1.14) |
0.43 |
42.2 (39.45;44.96) |
− 2.07 (− 4.23;0.08) |
0.06 | |
| T12 |
45.37 (42.67;48.07) |
0.22 (− 2.16;2.61) |
0.85 |
45.66 (41.93;49.39) |
1.38 (− 1.93;4.68) |
0.41 | |
| LDL cholesterol (mg/dl) | T0 |
90.02 (83.59;96.45) |
89.38 (81.29;97.46) |
||||
| T6 |
83.19 (74.8;91.58) |
− 6.83 (− 14.64;0.99) |
0.087 |
95.38 (85.85;104.91) |
6.00 (− 2.56;14.57) |
0.17 | |
| T12 |
80.37 (70.59;90.14) |
− 9.66 (− 18.92;− 0.39) |
0.04 |
82.55 (68.85;96.25) |
− 6.83 (− 19.66;6) |
0.29 | |
| Creatinine (mg/dl) | T0 |
0.94 (0.84;1.04) |
1.05 (0.92;1.18) |
||||
| T6 |
0.95 (0.85;1.06) |
0.01 (− 0.04;0.06) |
0.74 |
1.05 (0.91;1.19) |
0 (− 0.06;0.07) |
0.95 | |
| T12 |
0.95 (0.84;1.07) |
0.01 (− 0.06;0.08) |
0.75 |
1.07 (0.92;1.22) |
0.02 (− 0.07;0.11) |
0.70 | |
| eGFR (ml/min*1.73m2) | T0 |
80.7 (76.82;84.57) |
79.34 (74.33;84.35) |
||||
| T6 |
79.42 (75.1;83.74) |
− 1.28 (− 4.11;1.55) |
0.37 |
78.76 (73.29;84.23) |
− 0.58 (− 4.14;2.98) |
0.75 | |
| T12 |
80.63 (75.77;85.49) |
− 0.07 (− 3.69;3.56) |
0.97 |
78.43 (71.97;84.88) |
− 0.91 (− 5.74;3.92) |
0.71 | |
| Albuminuria (mg/dl) | T0 |
6.79 (3.75;9.82) |
9.93 (6.53;13.33) |
||||
| T6 |
4.88 (0.77;8.99) |
− 1.91 (− 6.65;2.84) |
0.43 |
5.49 (0.86;10.12) |
− 4.44 (− 9.65;0.77) |
0.09 | |
| T12 |
4.9 (− 0.76;10.56) |
− 1.88 (− 7.98;4.21) |
0.54 |
13.48 (6.91;20.04) |
3.54 (− 3.41;10.5) |
0.31 | |
| Semaglutide dose | T0 |
0.25 (0.22;0.29) |
0.57 (0.53;0.62) |
||||
| T6 |
0.82 (0.78;0.86) |
0.57 (0.52;0.61) |
< 0.0001 |
0.96 (0.91;.01) |
0.39 (0.33;0.44) |
< 0.0001 | |
| T12 |
0.86 (0.8;0.91) |
0.60 (0.54;0.67) |
< 0.0001 |
0.96 (0.88;1.03) |
0.38 (0.3;0.47) |
< 0.0001 | |
Changes in estimated mean levels of continuous end points during the follow-up and within-group comparisons (T6 vs. T0 and T12 vs. T0)
*Paired t-test derived from linear mixed models for repeated measurements. Statistically significant p values (p < 0.05) are in bold