Figure 3. FPRs are required for Cxcl2 responses to live streptococci.

• A–F
  Cxcl1 and Cxcl2 concentrations in 24‐h culture supernatants of neutrophils (A and B), CSF‐polarized (C and D) or GM‐CSF‐polarized (E and F) BMDMs (ΜΦ) from WT or Fpr‐deficient mice stimulated with live GBS (MOI of 2, 5, and 10) or HK‐GBS (10 µg/ml). LPS (100 ng/ml) was used as a positive control stimulus. Means + SD of data from three independent experiments conducted in duplicate. *P < 0.05, **P < 0.01, ***P < 0.001 vs. WT mice, determined by unpaired t‐test.