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. 2022 Feb 2;41(5):e109952. doi: 10.15252/embj.2021109952

Figure 1. Examples of site‐specific interactions and their combination in MVPs.

Figure 1

(A–E) Cartoon diagrams of various protein domains and proteins discussed in the text (yellow), with their cognate ligands shown in stick. (A) Src homology 3 (SH3) domain with proline‐rich motif (PRM); (B) Src homology 2 domain with tyrosine‐phosphorylated peptide; (C) Tudor domain with peptide from histone H3 trimethylated on lysine 36; (D) Importin‐β with Gly‐Leu‐Gly‐Phe (GLGF) peptide; (E) Enlargement of area boxed in D. The protein data bank (PDB) codes are indicated; (F) Domain organization of the NCK and N‐WASP proteins, and sequence of the proline‐rich region of N‐WASP (Uniprot, human sequence); and (G) Artificial multivalent constructs used by Li et al (2012).