Figure 4. Liquid like does not exclude SSIs.

(A) KNL1, an IDP at kinetochores, contains multiple sequence‐related phosphorylation sites for the recruitment of the BUB1/BUB3 complex, where BUB3 is a phospho–amino acid adaptor. KNL1 docks to CCAN in the core kinetochore. A FRAP experiment on BUB1/BUB3 and on a core kinetochore subunit would lead to fundamentally different conclusions on the nature of the compartment, as the core subunit do not exchange and would not recover, whereas BUB1/BUB3 would exchange in seconds; (B) Hand‐drawn curves representing the recovery behavior shown in A; (C) Two imaginary directly interacting MVPs in neighboring phase‐separated droplets (1 and 2, where the small differences in color are meant to recognize the origin of molecules in the original droplets) could easily mix if the interaction times of the individual modules allowed relatively rapid exchange.