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. 2022 Feb 2;41(5):e109952. doi: 10.15252/embj.2021109952

Figure 6. PS in the cavity of the nuclear pore complex.

Figure 6

(A) The Scaffold‐Nups subunits of the NPC (not shown individually) build a complex circular structure with a central cavity. The FG‐Nups (only a subset of which are shown) interact with the Scaffold‐Nups through SSIs. This allows to position their IDRs in the cavity of the pore, where they may form a hydrogel; (B) Domain organization of human NUP98, one of the human FG‐Nups. A short segment of the FG/GLFG sequence is shown; (C) An inert cargo molecule of sufficiently large size will be unable to cross the NPC cavity; (D) The cargo needs to bind to an import/export receptor like importin‐β, which binds the FG repeats, locally “melting” the meshwork, and therefore dissolving in it.