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Morphometric score (MRS) analysis for an example participant. For each participant, (a) each of the 75 ROIs are covariate corrected and normalised into z-scores; (b) each z-transformed ROI is weighted by the corresponding ROI effect size (Cohen’s d) from meta-analysis provided by ENIGMA-SCZ working group; (c) in ROIs where the z-score and SCZ-ENIGMA effect sizes are congruently signed. The SCZ-MRS reflects an average across these weighted ROIs.
