Fig. 2.

SOMCL-668 fails to improve phencyclidine-induced schizophrenia-related behaviors in sigma-1 receptor knockout mice. (A) PPI (%) was assessed using a startle stimulus intensity of 120 dB and prepulse intensities of 76, 83 and 87 dB. (B) Representative specimen traces of locomotor activity and summary bar graph of distance traveled. Social interaction (C) is presented as interaction time (s) and novel object recognition is presented as exploration time (s) for the familiar and novel objects (D) and as discrimination index (E). Data are shown as mean ± SEM; n = 10–12 mice per group. Statistical analysis was by two-way ANOVA; * P < .05, ** P < .01, *** P < .001.