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. 2021 Oct 8;48(2):514–523. doi: 10.1093/schbul/sbab122

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 2. — Longitudinal effects of ECT on GMV. Results of paired t tests for data at two time points (before and after ECT) in PMD and NPMD. GMV increased in widely distributed brain regions following ECT in both PMD and NPMD. Significance threshold was set at family-wise error-corrected P < .05 determined by threshold-free cluster enhancement. The color bars represent –log(P) (ie, 1.3 is equivalent to “P = .05”). Red represents regional GMV increase following ECT in PMD, and green represents regional GMV increase following ECT in NPMD. Yellow represents overlapped brain regions. Although there seems to be regional GMV increase specific to PMD or NPMD in the figure, there was no significant group-by-time interaction in a flexible factorial model. Abbreviations: ECT, electroconvulsive therapy; GMV, gray matter volume; NPMD, nonpsychotic major depression; PMD, psychotic major depression.