Table 1.
Pooled baseline characteristics in the total study cohort (k = 5)
| Baseline Characteristics | Total cohort (n = 688) | Cohort stabilized on OAP (n = 173) | Cohort stabilized on LAI (n = 515) | p-value* | |||
|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | ||
| Male | 398 | 57.8 | 94 | 54.33 | 304 | 59.0 | 0.29 |
| Region | |||||||
| Europe | 303 | 44.0 | 43 | 24.9 | 260 | 50.5 | <0.001 |
| Asia/Pacific | 193 | 28.0 | 107 | 61.8 | 86 | 16.7 | |
| North-America | 175 | 25.4 | 23 | 13.3 | 152 | 29.5 | |
| Central & South-America | 12 | 1.7 | 0 | 0.0 | 12 | 2.3 | |
| Africa | 5 | 0.7 | 0 | 0.0 | 5 | 1.0 | |
| Race | |||||||
| White | 373 | 54.2 | 61 | 35.3 | 312 | 60.6 | <0.001 |
| Asian | 153 | 22.2 | 71 | 41.0 | 82 | 15.9 | |
| African-American | 106 | 15.4 | 9 | 5.2 | 97 | 18.8 | |
| Other | 56 | 8.1 | 32 | 18.5 | 24 | 4.7 | |
| Smoking | 314 | 45.6 | 54 | 31.2 | 260 | 50.5 | <0.001 |
| At least moderate TD | 2 | 0.3 | 0 | 0.0 | 2 | 0.4 | 1.00 |
| At least moderate akathisia | 14 | 2.0 | 1 | 0.6 | 13 | 2.5 | 0.21 |
| At least moderate EPS | 77 | 11.2 | 23 | 13.3 | 54 | 10.5 | 0.33 |
| Mean | SD | Mean | SD | Mean | SD | ||
| Age | 37.8 | 11.2 | 35.2 | 11.4 | 38.64 | 10.98 | <0.001 |
| CGI-S | 2.7 | 0.7 | 2.7 | 0.71 | 2.70 | 0.72 | 0.67 |
| PANSS Total | 55.6 | 10.9 | 52.5 | 10.3 | 56.67 | 10.93 | <0.001 |
| PANSS General | 28.1 | 5.9 | 26.6 | 5.6 | 28.58 | 5.92 | <0.001 |
| PANSS Positive | 12.0 | 3.5 | 11.0 | 3.2 | 12.29 | 3.54 | <0.001 |
| PANSS Negative | 15.6 | 4.1 | 14.9 | 3.8 | 15.79 | 4.22 | 0.03 |
| PSP | 70.0 | 10.3 | 71.5 | 10.1 | 69.50 | 10.35 | 0.008 |
CGI-S: Clinical Global Impressions Severity score; EPS: Extrapyramidal symptoms; k: number of studies; n: number of individual participants; PANSS: Positive And Negative Syndrome Scale; PSP: Personal and social performance scale; SD: standard deviation; TD: Tardive dyskinesia.
*Fisher’s and Wilcoxon test for categorical and continuous variables respectively.