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Mediation analysis. (a) The ACE and ACME results of brain anatomical features on chronological age via blood parameters. (b) The ADE and ACME results of blood parameters on age via brain anatomical features. ACME, average causal mediation effects; ADE, average direct effects. The squares colored with gradient color from red to blue were for ADE or ACME values, and circle nodes with light brown to dark brown were for p value with significance
