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. 2022 Feb 22;7(9):8150–8157. doi: 10.1021/acsomega.2c00113

Figure 3.

Figure 3

(A) Fluorescence spectra from HNP1 and LL-37 peptide-conjugated GQDs in the presence and absence of GFP-tagged Baculovirus pseudotyped with a SARS-CoV-2 delta variant (B.1.617.2) spike protein. (B) TEM image of Baculovirus pseudotyped after they are treated with HNP1 human host defense peptide-attached GQDs for 30 min. (C) TEM image of Baculovirus pseudotyped after they are treated with HNP1 and LL-37 human host defense peptide-attached GQDs for 30 min. (D–H) Inhibition of SARS-CoV-2 spike protein binding to the surface of HEK-293T cells expressing ACE2. The green fluorescence is due to the presence of GFP-tagged Baculovirus pseudotyped with a SARS-CoV-2 delta variant (B.1.617.2) spike protein on the surface of HEK-293T cells expressing ACE2. (D) Fluorescence image of HEK-293T cells in the presence of GFP-tagged pseudotyped delta virus without GQDs. (E) Bright-field image of HEK-293T cells in the presence of GFP-tagged Baculovirus pseudotyped without GQDs. (F) Fluorescence image of HEK-293T cells in the presence of GFP-tagged virus bound with LL-37 human host defense peptide-attached GQDs. (G) Fluorescence image of HEK-293T cells in the presence of GFP-tagged virus bound with LL-37 & HNP1 human host defense peptide-attached GQDs. (H) Bright-field image of HEK-293T cells in the presence of GFP-tagged virus bound with LL-37 & HNP1 human host defense peptide-attached GQDs.