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. 2022 Mar 1;15:39. doi: 10.1186/s12920-022-01194-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Identification of prognostic ferroptosis-related DEGs in the GTEx and TCGA cohort. A Venn-diagram to obtain survival-related genes that were differentially expressed in tumor and adjacent non-tumor tissues. B Forest-plots displaying the 22 genes of the uniCox regression analysis in relationship with OS and gene expression. C Heatmap showing the expression of 22 overlapping genes in a single tissue. D Boxplot showing the difference in expression of intersection genes in tumor and normal tissues. E Interactive network displaying the relevance of 22 genes in TCGA cohort. F, G Correlation heatmap in STRING database and GeneMANIA database, respectively. H GO enrichment analysis of 22 genes in Metascape database