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. 2022 Mar 1;14:24. doi: 10.1186/s13073-022-01018-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Cell marker analysis in PanNEN subgroups identifies endocrine features in Group A. a Differentially methylated probes (DMPs) associated with pancreatic cell markers (n=770 probes). Each point represents a DMP. Dotted line: intersect between -Log10 P value and the log2 fold change (FC) for a given probe. Cut-off for significance: -Log10 P-value > 5 (adjusted p-value: 10⁻⁶) and log2FC: >|0.25|. Red: probes passing both cut-offs; green: probes only passing the log2FC threshold; blue: probes with only have a significant p-value; gray: probes that did not pass any of the cut-offs; Significantly associated DMP probes of IRX2 and NKX6-1 are labeled. b Methylation beta value of significant DMPs of pancreatic cell markers. Heatmap displaying the methylation beta values of DMPs (row) in each sample (column). Pancreatic cell-types which the cell marker is associated with, according to PanglaoDB, are displayed on the right. c Methylation beta value of probes associated with IRX2 and PDX1. DMP probes of IRX2 and 10K probes associated with PDX1 (rows) for each sample. Lower panel depicts recurrently mutated genes. d Representative IHC of ARX and PDX1 in PanNEN subgroups. Scale bar: 20μm