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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Eur Cell Mater. 2021 Sep 22;42:156–165. doi: 10.22203/eCM.v042a12

Fig. 1. Anti-Atl IgG4 antibody levels are decreased in bone infection patients.

Fig. 1.

AO Trauma CPP Bone Infection Registry baseline sera from uninfected patients (Ctrl, n = 92), infection controlled (IC, n = 95) patients, patients with adverse outcomes (AD, n = 40, fracture present, infection present, septic death, amputation, and definitive surgery at 1 year), and PM (n = 7) blood samples from osteomyelitis patients that died from S. aureus sepsis, were analysed for IgG antibodies specific for Amd and Gmd using a Luminex™ to determine: (a) total IgG MFI, (b) MFI for IgG4 specific antibodies, and (c) IgG4 MFI divided by total IgG MFI (RATIO). The data are presented for each patient with the median for the group. IgG4 to IgG RATIO represents the MFI for IgG4 divided by the MFI for total IgG normalised by Ctrl ratios such that the Ctrl median ratio is a value of 1. *p < 0.05, **p < 0.01, Wilcoxon rank-sum tests with adaptive Hochberg multiplicity adjustment.