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. 2021 Nov 25;50(4):e19. doi: 10.1093/nar/gkab1129

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Differential isoform usage of control and endogenous genes. Identification of DIU in the synthetic sequin gene R1_103 (A) and the potassium channel KCNQ2 (B). Top: structure of expressed isoforms. Arrows show direction of transcription. Narrow lines show intronic regions (not to scale). Exons displayed as boxes. Taller exonic boxes are coding regions, shorter boxes are 5′ and 3′ UTR regions. Colours represent identified protein domains. Below: graphs display gene and isoform expression and the fraction of expression corresponding to each isoform in Mix A/Undifferentiated and Mix B/differentiated samples. Red lines show known (expected) sequin isoform fractions in Mix A and B. ns = not significant, * < 0.05, ** < 0.01, *** < 0.001.