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. 2022 Feb 15;12:834485. doi: 10.3389/fcimb.2022.834485

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Copyright © 2022 Zhou, Sun, Yu and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dysregulated host molecules change the composition of the gut microbiota and thus contribute to the development of T2DM. Deletion of Sirtuin 1, ZnT8, FXR, Timp3, IL-36, TRIM31 and NABE-PLD, as well as overexpression of mTORC1, MGLL, ANGPTL4 and GLUT2, induce gut microbiota dysbiosis. ZnT8, Zinc transporter 8; FXR, Farnesoid X receptor; Timp3, Tissue inhibitor of metalloproteinase 3; IL-36, Interleukin 36; TRIM31, Tripartite motif-containing protein 31; NAPE-PLD, N-acylphosphatidylethanolamine phospholipase D; mTORC1, Mechanistic target of rapamycin complex 1; MGLL, Monoglyceride lipase; ANGPTL4, Angiopoietin-like 4; GLUT2, Glucose transporter 2.