Table 3.
AAT MM versus MZ Subjects with COPD in the ECLIPSE Study
| Characteristic | MM | MZ | P |
|---|---|---|---|
| n | 1,684 | 100 | — |
| Age, yr, mean (SD) | 63.31 (7.15) | 63.19 (6.40) | 0.870 |
| Sex, F, n (%) | 587 (34.9) | 32 (32.0) | 0.635 |
| Non-Hispanic White n (%) | 1,647 (97.8) | 96 (96.0) | 0.409 |
| Current smoker n (%) | 610 (36.2) | 27 (27.0) | 0.078 |
| Smoking pack-years, mean (SD) | 48.35 (27.00) | 47.21 (25.85) | 0.682 |
| Post-bronchodilator FEV1% predicted, mean (SD) | 48.52 (15.54) | 43.55 (16.48) | 0.002 |
| FEV1/FVC, mean (SD) | 0.45 (0.11) | 0.41 (0.11) | <0.001 |
| BODE index, mean (SD) | 3.13 (2.08) | 3.81 (2.42) | 0.002 |
| 6-min-walk distance, feet, mean (SD) | 1,219.71 (398.89) | 1,194.72 (404.09) | 0.553 |
| SGRQ total score, mean (SD) | 48.34 (18.37) | 49.82 (18.80) | 0.437 |
| MMRC dyspnea score, mean (SD) | 1.67 (1.05) | 1.89 (1.16) | 0.043 |
| GOLD stage, n (%) | |||
| 2 | 750 (44.5) | 34 (34.0) | 0.001 |
| 3 | 720 (42.8) | 41 (41.0) | |
| 4 | 214 (12.7) | 25 (25.0) | |
| Percentage of emphysema, mean (SD) | 17.03 (11.98) | 22.67 (13.06) | <0.001 |
| Perc15, mean (SD) | −949.93 (50.30) | −970.79 (45.73) | <0.001 |
| Pi10, mean (SD) | 4.40 (0.19) | 4.38 (0.20) | 0.325 |
| Segmental wall area percentage, mean (SD) | 65.77 (4.09) | 64.91 (3.78) | 0.048 |
Definition of abbreviations: AAT = alpha-1 antitrypsin; BODE = body mass index, airflow obstruction, dyspnea, and exercise; COPD = chronic obstructive pulmonary disease; CT = computed tomography; ECLIPSE = Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints; GOLD = Global Initiative for Chronic Obstructive Lung Disease; MM = PI MM genotype; MMRC = Modified Medical Research Council; MZ = PI MZ genotype; Perc15 = CT attenuation at the 15th percentile of the lung CT histogram; Pi10 = square root of the wall area of a theoretical airway with an internal perimeter of 10 mm; SGRQ = St. George’s Respiratory Questionnaire.
The percentage of emphysema is the percentage of lung voxels with CT attenuation ⩽−950 Hounsfield units at inspiratory CT.