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. 2022 Feb 28;19:58. doi: 10.1186/s12974-022-02421-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Altered cytokine mRNA expression in ALS compared to HC MDMi Box-and-whisker plot of mRNA expression of pro-inflammatory cytokines (IL-6, IL-8, TNFα, IL-1β, IL-18) and alternatively activated cytokines (IL-10, TGFβ) in HC and ALS MDMi. HC and ALS MDMi were differentiated for 14 days prior to the collection of supernatant. Data were first tested for normality using Shapiro–Wilk test. Statistical analysis between two groups was performed using Mann Whitney U tests. Values are the mean ± SD (*P < 0.05, **P < 0.01)