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[Preprint]. 2022 Feb 25:rs.3.rs-1280819. [Version 1] doi: 10.21203/rs.3.rs-1280819/v1

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Temporal analysis of polymutants in non-spike protein genes, in which locally averaged mutation percentages of every polymutant over time are shown in a row and is correspondingly colored from gray to dark red (color legend on the left side). By similarities/dissimilarities of their temporal patterns, all polymutants are clustered to six clusters (NS1, …, NS6), and numbers of polymutants in each cluster are indicated in bracket. B) Six polymutants with positive trajectories (in cluster NS3, 4, 5 and 6) are selected to illustrate their temporal patterns.