Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 1;36(3-4):225–240. doi: 10.1101/gad.348993.121

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Zheng et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Figure 7. — Distinct strategies for BEN domains to recognize DNA (A) AlphaFold2 predicts that several mammalian BEN domains (type I) have overall similar structures, including a substantial loop between α helices 3 and 4 and a long α helix 5. (B,B′) Both of these features are shared with DNA-binding contact regions in the Insv-BEN tertiary structure (PDB: 4IX7, in red), indicating that these BEN domains (type I) likely use similar strategies to interact with DNA. (C) The BEND3-BD4 domain contains a short loop in the C terminus that produces an α helix 6 (α6) and provides a channel to load DNA. RoseTTAFold predicts that several other BEN domains (type II) share this short “helix (α5)–loop–helix (α6)” structure, implying a shared strategy for DNA recognition. (D) Superposition of BEND3-BD4 and other predicted type II BEN domains predicted by RoseTTAFold.