Figure 4.

Ribosome proteins (RPs) that regulate translation in virus-infected cells. The figure depicts solvent and intrasubunit surfaces of 40S and 60S subunits with ribosomal RNA (gray) and RPs (tan). Highlighted RPs represent RPs important for virus IRES-mediated translation (green) or proviral functions (pink), or post-translationally modified during viral infection (blue). (Ribosome structure derived from PDB entry 4v88; figure based on data from Ben-Shem et al. [2011]).