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. 2021 Dec 6;50(4):e21. doi: 10.1093/nar/gkab1147

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Integration of eight scRNA-seq datasets on human pancreatic islets. The examined datasets span 27 samples, five technologies, and four laboratories. The examined integration methods include DESC, Harmony, LIGER, MNN, scAlign, Scanorama, scVI, Seurat V3 and VIPCCA. UMAPs are used for visualizing integration results by either technologies (A) or cell types (B). The overall integration quality is measured by four metrics: mixing metric (C), kBET acceptance rate (D), adjusted rand index (ARI) (E) and differential expression analysis (F).