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. 2022 Feb 7;50(4):2128–2142. doi: 10.1093/nar/gkac058

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Structure of the Sal(B)•ribosome complex. Sal(B) (purple) binds to the E-site of the ribosome (grey), with the interdomain linker of the former contacting and distorting the P-site tRNA (brown). ATP molecules coloured by atom. (A) Left; front view showing the NBDs of Sal(B) bound to the E site, in close proximity to the L1 stalk. Right; side view showing the C-terminal tail of Sal(B) wrapping around the 30S subunit. (B) Left; front view with transparent ribosome density to show the interdomain linker of Sal(B) reaching towards the peptidyl transferase centre (PTC) of the 50S ribosomal subunit, where LS_AP antibiotics bind. Right; top view showing the interaction of the interdomain linker of Sal(B) with the P-site tRNA.