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Antibiotic resistance profile of engineered variants of Sal-type proteins
| MIC (μg/ml) | ||||
|---|---|---|---|---|
| Construct expressing | Retapamulin | Tiamulin | Lincomycin | Clindamycin |
| empty vector (control) | 0.06 | 0.25 | 0.25 | 0.06 |
| Sal(B) (wild-type) | 8 | 16 | 8 | 1 |
| Sal(B)Y264L | 4 | 16 | 4 | 0.5 |
| Sal(B)Y264I | 4 | 16 | 4 | 0.5 |
| Sal(B)Y264S | 2 | 16 | 4 | 0.25 |
| Sal(B)Y264N | 2 | 16 | 8 | 1 |
| Sal (S. saprophyticus) | 0.06 | 0.25 | 0.25 | 0.06 |
| SalN264Y (S. saprophyticus) | 0.06 | 1 | 0.25 | 0.06 |
