Figure 1.

Conservation of regulatory network connections, regulatory elements, and transcriptomic tissue patterns. (A) The conservation of regulatory connections (RCs) represents the conservation of regulatory networks between humans and mice. (B) The conservation of regulatory elements (REs) was measured by detecting REs including enhancers and promoters in both species. If an enhancer was detected in one species, it was mapped as a species-specific enhancer. If an enhancer was found in both species, it was considered a conserved enhancer. (C) The conservation of gene expression was calculated by comparing tissue transcriptomes in humans and mice using ENCODE and FANTOM5.