Figure 4.

Conservation of regulatory elements, the regulatory network, and associated phenotypes. (A and B) Correlation between the conservation of regulatory connections and regulatory elements (REs): promoters (A) and enhancers (B). (C and D) Species-specific REs [promoters (C) and enhancers (D)] in regulatory networks for low phenotype similarity genes (LPGs) and high phenotype similarity genes (HPGs). (E and F) Examples of species-specific enhancers in regulatory networks of PHKG2 (LPGs) (E) and PKP2 (HPGs) (F).