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. 2022 Feb 15;50(4):2350–2362. doi: 10.1093/nar/gkac080

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Structure of YTH/(m⁶A)UCG tetraloop complex. (A) Crystal structure of YTH bound to the (m⁶A)UCG tetraloop of a Xist A-repeat. (B) The aromatic cage that recognizes the m⁶A is formed by W428, W377 and L439 side chains. (C) Hydrogen bonds (dashed lines) formed between S378, N367 and N363 mediate specific contacts to the m⁶A base. (D) A positively charged surface area interacts with the backbone of (m⁶A)UCG tetraloop and (E) mediates electrostatic interactions with the RNA (dashed lines). (F) π/cation stacking interaction between R475 and the U7 base.