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. 2022 Jan 31;50(4):2051–2073. doi: 10.1093/nar/gkac035

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Replication characteristics at TRIs. (A) Graphic representation of example of OK-Seq RFD data and interpretation at replication initiation and termination zones: slope correlates with origin localizartion, and amplitude correlates with origin efficiency. (B) Median OK-Seq signal profile scaled to full genes ±10 kb of TRI genes (green, n = 583), cTSS genes (red, n = 6558) and inactive TSS genes (purple, n = 11 612). Solid black arrows indicate initiation zones and dashed black arrows indicate termination zones. (C) Median TimEX signal profiles centered at TSS ± 1.0 Mb for TRI genes (green) and cTSSs genes (red). (D) Median TimEX signal profiles centered at TSS ± 200 Kb for TRI genes (green) and cTSSs genes (red). (E) Median EdU-Seq signal profiles on cells treated with 10 mM HU centered at TSSs for TRITSSs and cTSSs. (F) Median RPA ChIP-Seq signal profiles on cells treated with 10 mM HU centered at TSSs for TRITSSs and cTSSs For TRIs or TRITSS compared to cTSS, P < 1.0 × 10^–250; Wilcoxon rank sum test). *All profile plot analyses are performed in mBCs. Shaded areas on the unfilled line plots are the standard error.