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. 2022 Jan 31;50(4):2051–2073. doi: 10.1093/nar/gkac035

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — DNA breaks at TRIs. (A) Median signal profiles centered at TRIs of EdU-Seq (blue), EU-Seq (green) and END-Seq (orange) from 28 h NT cells. The EdU-Seq and END-Seq signal was multipled by 8 and 4 respectively so the signals can be seen clearly on the same scale. (B) Top graph showing the percentage of B cells in S and G2/M phases measured by PI incorporation and analyzed by FACS. Bottom of the panel showing END-Seq signal profile at 0, 12, 24, 28 and 72 h time points from NT cells centered near TSSs of TRITSSs (green) and cTSSs (red). (C) Median signal profiles of EU-Seq (top) and END-Seq 0 mM HU (bottom) of non-replicating resting (left) and 28 h activated replicating mouse B cells (right) centered near TSSs of TRITSSs (green), cTSSs (red) and inactive TSSs (purple). *All profile plot analyses are performed in mBCs. Shaded areas on the unfilled line plots are the standard error.