Table 1.

Linear variants of AS-48 bacteriocins present in the literature

Linear Variant	Sequence	Activity Retained?(Y/N)	Source
Syn-safencin	LSLIAAAGKETIRQYLKNEIKKKGRKAVIAW	Y	-
Library Parent	AGKETIRQYLKNEIKKKGRKAVIAW	Y	-
AS-48 49–69	ESIKAYLKKECKKKGKRACIA	N	Jimenez et al, 2005
AS-48 11–10	VAGTVLNVVEAGGWVTTIVSILTAVGSGGLSLLAAAGRESIKAYLKKEIKKKGKRAVIAWMAKEFGIPAA	Y	Montalban-Lopez et al, 2008
AS-48 43–27	LAAAGRESIKAYLKKEIKKKGKRAVIAWMAKEFGIPAAVAGTVLNVVEAGGWVTT	Y	Montalban-Lopez et al, 2008
AS-48 42,43–10	LLAAAGRESIKAYLKKEIKKKGKRAVIAWMAKEFGIPAA	Y	Montalban-Lopez et al, 2008

Note: W70 is highlighted in gold, M1 is highlighted in red, I59 and V67 are highlighted in blue, and unnatural cysteines are highlighted in orange. Y = linear variant retains antimicrobial activity. N = linear variant does not retain any antimicrobial activity